Miranda van Eck | BioPharmaceutics

Universiteit Leiden

Miranda van Eck, Dr.

Position:

Associate Professor

Telephone number: +31 (0)71 527 6238
E-mail address: m.eck@lacdr.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden/Amsterdam Center for Drug Research, BioPharmaceutics
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber HB 838

Biography: Dr. Van Eck studied Biopharmaceutical Sciences, specializing in Biopharmaceutics at the University of Leiden. After her graduation in 1994, she obtained her PhD from Leiden University in 1999. In 2001, Dr. Van Eck was appointed as Research Fellow of the Netherlands Heart Foundation. In 2005, she obtained a prestigious VIDI Award and became appointed as Assistant Professor. In 2007, Dr. Van Eck was appointed Established Investigator of the Netherlands Heart Foundation and became Associate Professor. Her research is focused upon the role of macrophage genes in the development of atherosclerosis with special emphasis on the function of genes involved in HDL metabolism and reverse cholesterol transport from the arterial wall to the liver. For her work she received twice a Pfizer International HDL Research Award.

2010

Ye, D., Meurs, I, Ohigashi, M., Calpe-Berdiel, L., Habets, K.L., Zhao, Y., Kubo, Y., Yamaguchi, A., Van Berkel, T.J., Nishi, T., Van Eck, M. , Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice, Biochem Biophys Res Commun, vol. 395, no. 3, pp. 387-94.

Zhao, Y., Van Berkel, T.J., Van Eck, M. , Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions, Curr Opin Lipidol.

Hildebrand, R.B., Lammers, B., Meurs, I, Korporaal, S.J., De Haan, W., Zhao, Y., Kruijt, J.K., Pratico, D., Schimmel, A.W., Holleboom, A.G., Hoekstra, M., Kuivenhoven, J.A., Van Berkel, T.J., Rensen, P.C., Van Eck, M. , Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency, Arterioscler Thromb Vasc Biol, vol. 30, no. 7, pp. 1439-45.

Hoekstra, M., Li, Z., Kruijt, J.K., Van Eck, M., Van Berkel, T.J., Kuiper, J. , The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status, J Hepatol, vol. 52, no. 2, pp. 244-51.

Meurs, I, Van Eck, M., Van Berkel, T.J. , High-density lipoprotein: key molecule in cholesterol efflux and the prevention of atherosclerosis, Curr Pharm Des, vol. 16, no. 13, pp. 1445-67.

2009

MacDonald, M.L., van Eck, M., Hildebrand, R.B., Wong, B.W., Bissada, N., Ruddle, P., Kontush, A., Hussein, H., Pouladi, M.A., Chapman, M.J., Fievet, C., van Berkel, T.J., Staels, B., McManus, B.M., Hayden, M.R. , Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis, Arterioscler Thromb Vasc Biol, vol. 29, no. 3, pp. 341-7.

Korporaal, S.J., Koekman, C.A., Verhoef, S., van der Wal, D.E., Bezemer, M., Van Eck, M., Akkerman, J.W. , Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2, Arterioscler Thromb Vasc Biol, vol. 29, no. 3, pp. 372-9.

Hoekstra, M., Lammers, B., Out, R., Li, Z., Van Eck, M., Van Berkel, T.J. , Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice, Mol Pharm, vol. 6, no. 1, pp. 182-9.

Lammers, B., Out, R., Hildebrand, R.B., Quinn, C.M., Williamson, D., Hoekstra, M., Meurs, I, Van Berkel, T.J., Jessup, W., Van Eck, M. , Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development, Atherosclerosis.

Guo, J., Bot, I, de Nooijer, R., Hoffman, S.J., Stroup, G.B., Biessen, E.A., Benson, G.M., Groot, P.H., Van Eck, M., Van Berkel, T.J. , Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice, Cardiovasc Res, vol. 81, no. 2, pp. 278-85.

Hoekstra, M., Ye, D., Hildebrand, R.B., Zhao, Y., Lammers, B., Stitzinger, M., Kuiper, J., Van Berkel, T.J., Van Eck, M. , Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production, J Lipid Res, vol. 50, issue 6, pp. 1039-46.

2008

Out, R., Jessup, W., Le Goff, W., Hoekstra, M., Gelissen, I.C., Zhao, Y., Kritharides, L., Chimini, G., Kuiper, J., Chapman, M.J., Huby, T., Van Berkel, T.J., Van Eck, M. , Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1, Circ Res, vol. 102, no. 1, pp. 113-20.

Van Eck, M., Hoekstra, M., Out, R., Bos, I.S., Kruijt, J.K., Hildebrand, R.B., Van Berkel, T.J. , Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo, J Lipid Res, vol. 49, no. 1, pp. 136-46.

Out, R., Hoekstra, M., Habets, K., Meurs, I, de Waard, V., Hildebrand, R.B., Wang, Y., Chimini, G., Kuiper, J., Van Berkel, T.J., Van Eck, M. , Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels, Arterioscler Thromb Vasc Biol, vol. 28, no. 2, pp. 258-64.

Ye, D., Hoekstra, M., Out, R., Meurs, I, Kruijt, J.K., Hildebrand, R.B., Van Berkel, T.J., Van Eck, M. , Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice, Atherosclerosis, vol. 196, no. 2, pp. 650-8.

Ye, D., Kraaijeveld, A.O., Grauss, R.W., Willems, S.M., van der Vark-van Zee, L.C., de Jager, S.C., Jauhiainen, M., Kuivenhoven, J.A., Dallinga-Thie, G.M., Atsma, D.E., Hogendoorn, P.C., Biessen, E.A., Van Berkel, T.J., Jukema, J.W., van Eck, . , Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes, J Intern Med, vol. 264, no. 6, pp. 571-85.

Hoekstra, M., Meurs, I, Koenders, M., Out, R., Hildebrand, R.B., Kruijt, J.K., Van Eck, M., Van Berkel, T.J. , Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting, J Lipid Res, vol. 49, no. 4, pp. 738-45.

2007

Pennings, M., Hildebrand, R.B., Ye, D., Kunne, C., Van Berkel, T.J., Groen, A.K., Van Eck, M. , Bone marrow-derived multidrug resistance protein ABCB4 protects against atherosclerotic lesion development in LDL receptor knockout mice, Cardiovasc Res, vol. 76, no. 1, pp. 175-83.

Westerterp, M., Van Eck, M., de Haan, W., Offerman, E.H., Van Berkel, T.J., Havekes, L.M., Rensen, P.C. , Apolipoprotein CI aggravates atherosclerosis development in ApoE-knockout mice despite mediating cholesterol efflux from macrophages, Atherosclerosis, vol. 195, no. 1, pp. e9-16.

Van Eck, M., Hoekstra, M., Hildebrand, R.B., Yaong, Y., Stengel, D., Kruijt, J.K., Sattler, W., Tietge, U.J., Ninio, E., Van Berkel, T.J., Pratico, D. , Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL, Arterioscler Thromb Vasc Biol, vol. 27, no. 11, pp. 2413-9.

Korporaal, S.J., Van Eck, M., Adelmeijer, J., Ijsseldijk, M., Out, R., Lisman, T., Lenting, P.J., Van Berkel, T.J., Akkerman, J.W. , Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A, Arterioscler Thromb Vasc Biol, vol. 27, no. 11, pp. 2476-83.

Van Eck, M., Ye, D., Hildebrand, R.B., Kar Kruijt, J., de Haan, W., Hoekstra, M., Rensen, P.C., Ehnholm, C., Jauhiainen, M., Van Berkel, T.J. , Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice, Circ Res, vol. 100, no. 5, pp. 678-85.

Vikstedt, R., Ye, D., Metso, J., Hildebrand, R.B., Van Berkel, T.J., Ehnholm, C., Jauhiainen, M., Van Eck, M. , Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development, Arterioscler Thromb Vasc Biol, vol. 27, no. 3, pp. 578-86.

Out, R., Hoekstra, M., Meurs, I, de Vos, P., Kuiper, J., Van Eck, M., Van Berkel, T.J. , Total body ABCG1 expression protects against early atherosclerotic lesion development in mice, Arterioscler Thromb Vasc Biol, vol. 27, no. 3, pp. 594-9.

Herczenik, E., Bouma, B., Korporaal, S.J., Strangi, R., Zeng, Q., Gros, P., Van Eck, M., Van Berkel, T.J., Gebbink, M.F., Akkerman, J.W. , Activation of human platelets by misfolded proteins, Arterioscler Thromb Vasc Biol, vol. 27, no. 7, pp. 1657-65.

Miranda currently supervises the following students:

Erik van Kampen

10/06/2009

BioPharmaceutics