Menno Hoekstra | BioPharmaceutics

Universiteit Leiden

Menno Hoekstra, Dr.

Position:

Postdoc

Telephone number: +31 (0)71 527 6238
E-mail address: hoekstra@lacdr.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden/Amsterdam Center for Drug Research, BioPharmaceutics
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber 838

Biography: Dr. Menno Hoekstra studied Biopharmaceutical Sciences, specializing in Toxicology and Medical Pharmacology at the University of Leiden. After his graduation in 2001, he obtained his PhD from Leiden University in 2005 for his thesis entitled “Modulation of hepatic gene expression: implications for lipid metabolism”. Since 2005, Menno Hoekstra has been working within the Division of Biopharmaceutics as a Postdoctoral Fellow with an interest on therapeutic modulation of lipid metabolism for the treatment of atherosclerosis. In 2008, he received a prestigious personal Grant (Dekker 2008T070) from the Netherlands Heart Foundation to study the role of the adrenals in cardiovascular disease.

2010

Hildebrand, R.B., Lammers, B., Meurs, I, Korporaal, S.J., De Haan, W., Zhao, Y., Kruijt, J.K., Pratico, D., Schimmel, A.W., Holleboom, A.G., Hoekstra, M., Kuivenhoven, J.A., Van Berkel, T.J., Rensen, P.C., Van Eck, M. , Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency, Arterioscler Thromb Vasc Biol, vol. 30, no. 7, pp. 1439-45.

Hoekstra, M., Li, Z., Kruijt, J.K., Van Eck, M., Van Berkel, T.J., Kuiper, J. , The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status, J Hepatol, vol. 52, no. 2, pp. 244-51.

Hoekstra, M., van der Lans, C.A., Halvorsen, B., Gullestad, L., Kuiper, J., Aukrust, P., van Berkel, T.J., Biessen, E.A. , The peripheral blood mononuclear cell microRNA signature of coronary artery disease, Biochem Biophys Res Commun, vol. 394, no. 3, pp. 792-7.

2009

de Haan, W., de der Vries-van Weij, J., Mol, I.M., Hoekstra, M., Romijn, J.A., Jukema, J.W., Havekes, L.M., Princen, H.M., Rensen, P.C. , PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice, Biochim Biophys Acta, vol. 1791, no. 3, pp. 191-7.

Hoekstra, M., Lammers, B., Out, R., Li, Z., Van Eck, M., Van Berkel, T.J. , Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice, Mol Pharm, vol. 6, no. 1, pp. 182-9.

Lammers, B., Out, R., Hildebrand, R.B., Quinn, C.M., Williamson, D., Hoekstra, M., Meurs, I, Van Berkel, T.J., Jessup, W., Van Eck, M. , Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development, Atherosclerosis.

Hoekstra, M., Ye, D., Hildebrand, R.B., Zhao, Y., Lammers, B., Stitzinger, M., Kuiper, J., Van Berkel, T.J., Van Eck, M. , Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production, J Lipid Res, vol. 50, issue 6, pp. 1039-46.

2008

de Haan, W., van der Hoogt, C.C., Westerterp, M., Hoekstra, M., Dallinga-Thie, G.M., Princen, H.M., Romijn, J.A., Jukema, J.W., Havekes, L.M., Rensen, P.C. , Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice, Atherosclerosis, vol. 197, no. 1, pp. 57-63.

Out, R., Jessup, W., Le Goff, W., Hoekstra, M., Gelissen, I.C., Zhao, Y., Kritharides, L., Chimini, G., Kuiper, J., Chapman, M.J., Huby, T., Van Berkel, T.J., Van Eck, M. , Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1, Circ Res, vol. 102, no. 1, pp. 113-20.

Van Eck, M., Hoekstra, M., Out, R., Bos, I.S., Kruijt, J.K., Hildebrand, R.B., Van Berkel, T.J. , Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo, J Lipid Res, vol. 49, no. 1, pp. 136-46.

Out, R., Hoekstra, M., Habets, K., Meurs, I, de Waard, V., Hildebrand, R.B., Wang, Y., Chimini, G., Kuiper, J., Van Berkel, T.J., Van Eck, M. , Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels, Arterioscler Thromb Vasc Biol, vol. 28, no. 2, pp. 258-64.

Ye, D., Hoekstra, M., Out, R., Meurs, I, Kruijt, J.K., Hildebrand, R.B., Van Berkel, T.J., Van Eck, M. , Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice, Atherosclerosis, vol. 196, no. 2, pp. 650-8.

Hoekstra, M., Meurs, I, Koenders, M., Out, R., Hildebrand, R.B., Kruijt, J.K., Van Eck, M., Van Berkel, T.J. , Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting, J Lipid Res, vol. 49, no. 4, pp. 738-45.

2007

Van Eck, M., Hoekstra, M., Hildebrand, R.B., Yaong, Y., Stengel, D., Kruijt, J.K., Sattler, W., Tietge, U.J., Ninio, E., Van Berkel, T.J., Pratico, D. , Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL, Arterioscler Thromb Vasc Biol, vol. 27, no. 11, pp. 2413-9.

Van Eck, M., Ye, D., Hildebrand, R.B., Kar Kruijt, J., de Haan, W., Hoekstra, M., Rensen, P.C., Ehnholm, C., Jauhiainen, M., Van Berkel, T.J. , Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice, Circ Res, vol. 100, no. 5, pp. 678-85.

Out, R., Hoekstra, M., Meurs, I, de Vos, P., Kuiper, J., Van Eck, M., Van Berkel, T.J. , Total body ABCG1 expression protects against early atherosclerotic lesion development in mice, Arterioscler Thromb Vasc Biol, vol. 27, no. 3, pp. 594-9.

van der Hoogt, C.C., de Haan, W., Westerterp, M., Hoekstra, M., Dallinga-Thie, G.M., Romijn, J.A., Princen, H.M., Jukema, J.W., Havekes, L.M., Rensen, P.C. , Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression, J Lipid Res, vol. 48, no. 8, pp. 1763-71.

2006

Pennings, M., Meurs, I, Ye, D., Out, R., Hoekstra, M., Van Berkel, T.J., Van Eck, M. , Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development, FEBS Lett, vol. 580, no. 23, pp. 5588-96.

Out, R., Hoekstra, M., Hildebrand, R.B., Kruit, J.K., Meurs, I, Li, Z., Kuipers, F., Van Berkel, T.J., Van Eck, M. , Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice, Arterioscler Thromb Vasc Biol, vol. 26, no. 10, pp. 2295-300.

Hoekstra, M., Stitzinger, M., van Wanrooij, E.J., Michon, I.N., Kruijt, J.K., Kamphorst, J., Van Eck, M., Vreugdenhil, E., Van Berkel, T.J., Kuiper, J. , Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet, J Lipid Res, vol. 47, no. 10, pp. 2198-207.

Post, S.M., Groenendijk, M., van der Hoogt, C.C., Fievet, C., Luc, G., Hoekstra, M., Princen, H.M., Staels, B., Rensen, P.C. , Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol, Arterioscler Thromb Vasc Biol, vol. 26, no. 12, pp. 2724-30.

2005

van Berkel, T.J., Out, R., Hoekstra, M., Kuiper, J., Biessen, E., van Eck, M. , Scavenger receptors: friend or foe in atherosclerosis?, Curr Opin Lipidol, vol. 16, no. 5, pp. 525-35.

Meurs, I, Hoekstra, M., van Wanrooij, E.J., Hildebrand, R.B., Kuiper, J., Kuipers, F., Hardeman, M.R., Van Berkel, T.J., Van Eck, M. , HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes, Exp Hematol, vol. 33, no. 11, pp. 1309-19.

Hoekstra, M., Out, R., Kruijt, J.K., Van Eck, M., Van Berkel, T.J. , Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells, J Hepatol, vol. 42, no. 3, pp. 400-7.

Out, R., Hoekstra, M., de Jager, S.C., de Vos, P., van der Westhuyzen, D.R., Webb, N.R., Van Eck, M., Biessen, E.A., Van Berkel, T.J. , Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice, J Lipid Res, vol. 46, no. 6, pp. 1172-81.

04/06/2009

BioPharmaceutics