- Mission
Atherosclerosis is the main underlying pathology of cardiovascular disease, which is still a major cause of death in the Western society and results from complex interactions between gene products involved in lipoprotein metabolism, inflammation, thrombosis, and vessel-wall structure. Read more about our reserch in the research section.
Introduction
Highlights
- Augmented Atherogenesis in LDL Receptor Deficient Mice Lacking Both Macrophage ABCA1 and ApoE
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Bart Lammers
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- Growth Differentiation Factor-15 Deficiency Protects Against Atherosclerosis by Attenuating CCR2 Mediated Macrophage Chemotaxis
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Saskia C.A. de Jager
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- Function human receptor for good cholesterol unmasked
HDL is known as the “good cholesterol”: it lowers the chance of developing cardiovascular disease. Some families display naturally high levels of HDL in their blood. Research on the underlying causes of genetically high HDL cholesterol is important for the development of new medicines that can increase HDL levels in the blood.
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- Dr. Ilze Bot: Substance P Induces Plaque Destabilization
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In a publication in Circulation Research, Dr. Ilze Bot from the Division of Biopharmaceutics describes how the Neuropeptide P Mediates Adventitial Mast Cell Activation and Induces Intraplaque Hemorrhage in Advanced Atherosclerosis.
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